European Journal of Biomedical and Pharmaceutical Sciences

MOLECULAR DOCKING STUDIES OF SIDDHA MEDICINE INJI CHOORANAM II ON ANTI HYPERLIPIDEMIC ACTIVITY

C. Sowndarya*, J. S. Jerfin, A. Safeeq Ahamed, B. Arthi and V. Mahalakshmi

ABSTRACT

Hyperlipidemia is a condition characterized by increased levels of lipids such as cholesterol and triglycerides in the blood. Hyperlipidemia is a medical disorder characterized by an increase in one or more plasma lipids, plasma lipoproteins and low density-lippoprotein, and decrease in high density-lipoproteins. Several medicinal herbs have been shown in studies to lower blood cholesterol levels by decreasing the action of 3-hydroxy -3-methylglutaryl co enzyme a reductase (HMG-CoA). Molecular docking has become increasingly important as a method for drug discovery. The aim of the study is to evaluate natural products against hyperlipidemia using molecular docking. The increase likely due to a combination of factor, including unhealthy dietary habits, physical inactivity and obesity. Binding of phytocomponents with the core amino acids (Ser 684, Asp690, Lys691, Lys 692) of the target by forming hydrogen bond will hinder the function of the enzyme HMG CoA reductase with PDB-1HWK.These amino acid residues are functionally responsible for HMG CoA reductase enzyme activity in cholesterol biosynthesis. The phytocomponents which inhibit the target enzyme HMG CoA reductase by occupies these active aminoacid could be able to hinder the function of rate limiting enzyme involved in cholesterol biosynthesis.

Keywords: Hyperlipidemia, Molecular Docking, Siddha Herbal Medicine, Inji Chooranam II.