European Journal of Biomedical and Pharmaceutical Sciences

THERAPEUTIC POTENTIAL OF DIAZOXIDE CHOLINE CONTROLLED RELEASE DRUG IN TREATING OBESITY - A REVIEW

B. Premkumar*, G. Saroj, M. D. Swetha, D. Keshika, S. Mohamed Shehal, P. R. Roshan Khumaar, M. Pradeepkumar, K. Samunesh and K. Karthick

ABSTRACT

Obesity is a chronic, multifactorial disease associated with significant morbidity and mortality. Traditional therapeutic approaches often fall short due to issues such as poor patient compliance, adverse effects, and limited efficacy. Diazoxide choline, a novel ATP-sensitive potassium KATP channel opener, has emerged as a potential pharmacological agent in obesity management due to its ability to modulate insulin secretion and metabolic pathways. This review explores the pharmacological profile, mechanism of action, formulation strategies, and clinical relevance of Diazoxide choline-controlled release (CR) systems in the treatment of obesity. The controlled release formulation ensures sustained therapeutic action, minimizes adverse effects, and enhances patient adherence. Understanding the potential of Diazoxide choline CR can help in advancing obesity pharmacotherapy and formulating personalized treatment approaches.

Keywords: Diazoxide choline, controlled release, obesity, KATP channel opener, metabolic modulation, anti-obesity drugs.