Abstract
A STUDY ON NOOTROPIC ACTIVITY OF WHOLE PLANT EXTRACT OF PERGULARIA DAEMIA IN MICE AND RATS

Parmeshappa B., M. Veeresh*, MD Shamsuddin Muunawar, Prajwal K., Jayashree B. Kattimani and Pooja Rathod

ABSTRACT

Nootropic activity was evaluated with the aqueous extract of whole plant of Pergularia daemia (AQEWPPD) on exteroceptive behavior & interoceptive behavior by using shock box & shuttle box. Albino mice and Rats were administered with different doses of AQEWPPD low (100mg /kg), Medium(200mg/kg) and High (400mg/kg) daily per oral. The results were compared to Piracetam (100mg/kg p.o) which served as a standard drug. The buzzer (conditioned stimulus) and an electric shock (unconditioned stimulus, 30 v and 0.5 sec) were used in the Shuttle box. The plant extracts have shown statistically significant improvement in memory retention and learning when compared to standard. The study shows that Pergularia daemia extract has dose-dependent cholinergic activity to improve memory. In light of the above, it may be worthwhile to explore the potential of Pergularia daemia in the management of Dementia patients.

Keywords: Nootropics, Dementia, Pergularia daemia, Shock box, Shuttle box.


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