Abstract
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF INDAPAMIDE AND NEBIVOLOL IN BULK AND PHARMACEUTICAL DOSAGE FORM

Mohit R. Yewale*, Rajesh G. Jadhao, Dr. Dipak D. Kumbhar, Suraj S. Patil and Dr. Parag R. Patil

ABSTRACT

A simple Reverse phase liquid chromatographic method has been developed and subsequently validated for estimation of Indapamide (IDP) and Nebivolol (NBV) in bulk and tablet dosage form. The separation was carried out using a mobile phase consisting of Methanol and Water (0.1% TFA) in the ratio of 35:65. The column used was C18 (100mm×4.6mm) and 2.5 µm particle size with flow rate of 1 ml / min using UV detection at 257nm. The described method was linear over a concentration range of 1.5-7.5 ppm for Indapamide and 5-25 ppm for Nebivolol. The retention time of IDP was found to be 5.5 min and for NBV its 7.8 min, and all the results of analysis were validated statistically. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Indapamide and Nebivolol in bulk and tablet dosage form.

Keywords: Indapamide, Nebivolol, HPLC, Tablets, Assay, UV, Standard, Validation, Linearity, Accuracy, Precision, Ruggedness.


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