European Journal of Biomedical and Pharmaceutical Sciences

HEPATOPROTECTIVE ACTIVITY OF SESBANIA CANNABINA SEED EXTRACT ON EXPERIMENTAL RATS

Wajahat Khan*, Vinod Kumar Dhote, Kanika Dhote and Surendra Jain

ABSTRACT

Liver diseases continue to be a major global health concern, often resulting from exposure to environmental toxins, drugs, and unhealthy lifestyle practices. In search of effective hepatoprotective agents, medicinal plants offer promising therapeutic potential. This study evaluates the hepatoprotective effect of Sesbania cannabina seed extract in Wistar albino rats with carbon tetrachloride (CCl₄)-induced liver injury. Rats were divided into five groups: Normal Control, Toxin Control, Silymarin Treated (100 mg/kg), and two groups receiving low (200 mg/kg) and high (400 mg/kg) doses of the plant extract. Over 14 days, the treatment groups were assessed for liver function biomarkers (ALT, AST, ALP, total bilirubin), antioxidant activity, and histopathological changes. Methanolic extracts were prepared using Soxhlet extraction. The results demonstrated that Sesbania cannabina seed extract significantly restored liver enzyme levels, improved antioxidant defenses, and preserved liver histology in a dose-dependent manner, comparable to the standard hepatoprotective agent silymarin. These findings suggest that Sesbania cannabina possesses potent hepatoprotective and antioxidant properties, supporting its traditional medicinal use and potential for therapeutic development.

Keywords: Sesbania cannabina, Hepatoprotective activity, Carbon tetrachloride (CCl?), Liver injury, Liver function biomarkers.