Abstract
IDENTIFICATION OF SECRETION SYSTEM AND PHYLOGENETIC ANALYSIS OF MYCOBACTERIUM ON THE BASIS SS GENES

Muhammad Taimoor Khan, Shazia Mannan, Shafeeq-Ur-Rehman and Shahid Raza*

ABSTRACT

Pathogenic bacteria depend on secretory pathways for the performance of virulence functions and one of the most important bacteria is mycobacterium. Recently, a novel type of secretory pathway, type VII secretion systems (T7SSs), has been characterized in mycobacteria. The chromosomes of Mycobacterium tuberculosis and Mycobacterium bovis encode five T7SS`s (ESX-1 to ESX-5). The best characterized of them, ESX-1, is involved in host-pathogen interactions and its deletion is one of the main causes of M. bovis BCG attenuation. Type 7 secretion system is reported to be found in mycobacterial species. This study is mainly conducted to identify and detect the presence of secretion system gene clusters in Mycobacterial species and to check the closeness and relativity among different species on the basis of secretory pathway present in them.

Keywords: T7SS`s (ESX-1 to ESX-5), M. bovis BCG.


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