European Journal of Biomedical and Pharmaceutical Sciences

COMPARATIVE EVALUATION OF OZENOXACIN AND CLINDAMYCIN IN ACNE MANAGEMENT

Praveen Kumar Rathore, Akanksha Singh, Harshvardhan Namdeo, Pushpendra Singh, Akanksha Singh*, Dr. Arpit Singh

ABSTRACT

Background: Acne vulgaris is a prevalent dermatological condition, particularly among adolescents and young adults, often leading to both physical and psychosocial challenges. Among available treatment modalities, topical antibiotics continue to play a pivotal role in its management. Objective: This study aimed to assess and compare the therapeutic efficacy and tolerability of topical clindamycin 1% and ozenoxacin 2% in individuals presenting with mild to moderate acne vulgaris. Methods: A randomized, double-blind pilot study was conducted involving 20 participants diagnosed with mild to moderate acne. Subjects were randomly assigned to two groups: one received clindamycin 1% lotion (Group A), and the other received ozenoxacin 2% lotion (Group B), both applied twice daily over eight weeks. Clinical evaluation included the Global Acne Grading System (GAGS) and the Leeds Revised Acne Grading System to measure inflammatory and non-inflammatory lesion counts. Secondary assessments comprised patient satisfaction and adverse effects. Data were analyzed using SPSS version 23.0, with Student’s t-test and chi-square tests applied as appropriate. Results: Both treatment groups exhibited significant reductions in lesion counts from baseline. Ozenoxacin demonstrated a slightly superior reduction in inflammatory lesions, while clindamycin showed a marginally better effect on non-inflammatory lesions. Participants in the ozenoxacin group also reported higher satisfaction and fewer side effects. Conclusion: Both clindamycin and ozenoxacin were effective in treating mild to moderate acne. Ozenoxacin may provide enhanced anti-inflammatory benefits and better patient tolerance. Further research with larger sample sizes is necessary to substantiate these findings.

Keywords: Acne vulgaris; clindamycin; ozenoxacin; topical antibiotics; comparative efficacy; pilot study.