European Journal of Biomedical and Pharmaceutical Sciences

PHARMACEUTICAL FORMULATION AND IN-VITRO EVALUATION OF CEPHALOSPORIN –BASED CHEWABLE TABLETS

*Dr. Deovrat Kumar, Shalini Sharma, Aryavrat

ABSTRACT

Antimicrobial agents are among the most commonly used drugs, and are often misused. The in evitable consequence of the widespread use of antimicrobial agents has been the emergence of antibiotic- resistant pathogens and the ever-increasing need for new drugs. Antibiotics are substances produced by various species of microorganisms (bacteria, fungi, and actinomycetes) that suppress the growth of other microorganisms. Some factors alter the action of antibiotics, such as pharmacokinetic factors and route of administration. For therapy to be effective, the drug must reach a level that stops or kills bacteria at the infection site without hurting the patient. To achieve this, we need to consider how the drug moves in the body and other factors related to the patient. Ceftazidime is a 3rd generation broad spectrum β- Lactam cephalosporin class of antibiotic administered orally in pediatric and adult patients.To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ceftazidime and other antibacterial drugs.

Keywords: Cephalosporin, Chewable tablets, Formulation, In-vitro evaluation, Pediatric formulation, Oral antibiotics, Dispersible tablets.