REVIEW ARTICLE ON DRUG DESIGN
K. Malleswari*, Dr. D. Rama Brahma Reddy, K. Sirisha, K. Ludiyana Nirmala, M. Sowjanya Preethi Chandra
ABSTRACT
Pharmaceutical drug discovery is an expensive and time consuming process. The development of a drug from an initial idea to its entry into the market is a very complex process which can take around 5-10 yrs. and cost is very high upto billion. It is an development process involves use of variety of computational techniques, such as structure activity relationship, quantitative structure activity relationship, molecular mechanics, quantam mechanics, molecular dynamics and drug protein docking. The idea for a new development can come from a variety of sources which include the current necessities of the market, new emerging diseases, academic and clinical research, commercial sector. The pharmaceutical industry is under pressure in developing cost effectiveness drug molecule from the previous knowledge and established Quantitative Structure Activity Relationship. The structure based design is one of reliable and promising techniques used in drug designing. In drug design, the main aim is to find out the three dimensional structure of pharmacologically significant receptor ligand complexes. The aim of this review is to give an overview on the rational drug design approaches with a case study on drug discovery for influenza A virus, HER2 Receptor, targeting dopamine D3 receptor, purpose, and applications of QSAR. This article highlight the benefits and promises of developing tools for drug discovery.
Keywords: OSAR, docking, pharmacore.
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