European Journal of Biomedical and Pharmaceutical Sciences

DESIGN AND DEVELOPMENT OF PINAVERIUM BROMIDE LOADED COLON TARGETING NANOSPONGES USING PH SENSITIVE POLYMERS

Pulkit Kirar, Vinod Dhote*, Kanika Dhote, Surendra Jain

ABSTRACT

Irritable Bowel Syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits without any detectable structural or biochemical abnormalities. Due to its complex and multifactorial nature, current treatment strategies primarily offer symptomatic relief rather than a definitive cure. This paper explores the potential of a novel drug delivery system—nanosponges—to address the challenges of IBS management. Nanosponge-loaded gels were formulated and evaluated for their physicochemical properties and in vitro drug release profile. The study aimed to create a stable and effective delivery system that could offer sustained release of a therapeutic agent for localized treatment of IBS symptoms. The results from the optimized formulation demonstrated high percentage yield, excellent entrapment efficiency, and a controlled release profile, indicating that nanosponges are a promising approach for the management of this condition.

Keywords: Irritable Bowel Syndrome, nanosponges, sustained release, colon targeting.