M2 PYRUVATE KINASE IN COLORECTAL CANCER IN ANEMIC PATIENTS
Mohamed Metwallya, Mohammed Mohammed Shamseyab, Ahmed E. Alakanyc, Mohamed M. El Sawyd,
El-Moughazi AM.e*
ABSTRACT
Background: Colorectal cancer (CRC) is a disease with a major impact on public health and public health costs.
Colonoscopy is the gold standard screening tool for CRC. However, its acceptance by the general population is
relatively low; hence evaluation of other non-invasive screening tools is essential. M2 pyruvate kinase (M2PK)
appears to be a good candidate, yet its accuracy is not yet fully assessed. Aims: To Estimate sensitivity,
specificity, positive (PPV) and negative (NPV) predictive value of M2PK relative to colonoscopy in screening of
CRC in anemic patients with unexplained bleeding per rectum and unintentional weight loss in Egypt. Methods:
Thirty consecutive cases of anemia complaining of unexplained bleeding per rectum and unintentional weight loss
were subjected after taking informed consent to colonoscopy and multiple biopsies were taken for
histopathological assessment. Fecal tumor M2PK level was measured using an ELISA kit in both groups. Results:
Sensitivity was (75%), specificity (60%), PPV (78%) and NPV (54.5%). Conclusion: Measurement of tumor
M2PK in stool seems to be a promising tool for CRC screening at present time in combination with colonoscopy.
Keywords: Colorectal cancer, Colonoscopy, M2PK, Egypt, Screening.
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