EXPLORING STIMULI-SENSITIVE HYDROGELS: INNOVATIONS IN SMART DRUG DELIVERY MECHANISMS
Yash Anil Chaudhari*, Vaishnavi Jitendra Patil, Sakshi Sudharshan Jadhav, Akanksha Pandit Amrutkar, Jagruti Javaharlal Patil, Latika Raghunath Gavali, Mr. Mohammed Awais, Mr. Saeed Ahmad
ABSTRACT
Smart hydrogels are sophisticated materials that react to electric impulses, temperature, pH, and glucose levels, among other external stimuli. The capacity of these hydrogels to release medications at the appropriate time and location has drawn interest in drug delivery systems. Treatments for cancer, eyes, and skin can benefit from temperature-sensitive hydrogels, such as those derived from PNIPAAm, which release medications when they reach body temperature. Hydrogels that are sensitive to pH react to variations in acidity and are perfect for targeted administration in the intestines or stomach.By reacting to blood sugar levels, glucose-sensitive hydrogels assist diabetic patients in managing the release of insulin. When activated externally, other varieties, such electric and light-sensitive hydrogels, provide rapid medication release. Despite their potential, these systems still have issues with immunological responses, limited biodegradability, and delayed response times. Nowadays, research is concentrated on creating hydrogels that are fast-acting, biocompatible, and multiresponsive in order to increase drug delivery accuracy. In the future, these intelligent hydrogels may greatly improve patient care and therapeutic efficacy.
Keywords: Environment-sensitive hydrogels, Drug delivery, Stimuli-sensitive hydrogels.
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