FORMULATION AND CHARACTERIZATION OF CHITOSAN MICROSPHERE AS A CARRIER OF SUNSCREEN AGENT
Deepanjali Singh Gaharwar*, Abhishek Dwivedi, Deepak
ABSTRACT
Oxybenzone, a broad spectrum sunscreen agent widely used in the form of lotion and cream, has been reported to cause skin irritation, dermatitis, and systemic absorption. The objective of the present study was to formulation and characterization of chitosan microsphere as carrier of sunscreen agent. The formulation and characterization of an Oxybenzone-loaded microsphere drug delivery system were comprehensively studied and optimized using the Box–Behnken statistical design approach. The drug's solution pH was 7.8 (slightly alkaline), and the melting point was observed at 62°C, consistent with standard references, confirming its identity and purity. The Lambda max was found at 289.0 nm, UV spectrophotometric analyses. For particle size, the linear model was significant (F = 14.33, p = 0.0014), with a strong adjusted R² of 0.9842. For entrapment efficiency, the linear model also proved significant (F = 14.92, p = 0.0012), adjusted R² = 0.7915. In both responses had a statistically significant effect (p < 0.0002). The microsphere was spherical with Particle size in the range of 0.10–0.22 μm. The optimized formulation possesses the particle size of +519.96 + 61.22A – 35.36B – 299.41C and entrapment efficiency of +84.23 + 0.5112A – 0.2150B + 8.52C, respectively. This microsphere formulation of Oxybenzone may serve as a promising candidate for topical or cosmetic applications, offering controlled release and improved performance over conventional formulations.
Keywords: Oxybenzone, chitosan microsphere, Entrapment efficiency, Lambda max.
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