ASSESSMENT OF PAIN-RELIEVING POTENTIAL AND NEUROPHARMACOLOGICAL ACTIVITIES OF NYCTANTHES ARBOR-TRISTIS AND CLITORIA TERNATEA IN SWISS ALBINO MICE
Keerthi Birudaraju*, Sara Fathima, Potharaju Anitha, Chennuri Akshitha, Chennaboina Soumya, Donpal Rajesh, Devuni Saivarsha, Dugyala Maruthi, Sripadha Vallabha
ABSTRACT
Background: Nyctanthes arbor-tristis and Clitoria ternatea are two examples of traditional herbs that have recently come to attention due to the growing need for better, safer options in the treatment of neurological disorders and pain. The synergistic effects of these two substances have been understudied despite their well-documented neuroactive and analgesic potential. Methods: Mice were used for acute toxicity testing and phytochemical screening of a combination of N. arbor-tristis and C. ternatea extracts. Hot plate and tail flick tests were used to assess the extract's analgesic effects, while forced swim, tail suspension, light-dark box, and open field tests were used to assess its neuropharmacological effects. The results were compared to those of conventional medications. Results: The extract showed analgesic effectiveness in hot plate and tail flick experiments, where the latency increased in a dose-dependent manner. There was a significant decrease in both immobility time and locomotor activity in the neuropharmacological tests, which might indicate antidepressant and anxiolytic effects. The exact action mechanism, however, is yet unknown. Conclusion: At 100 mg/kg, the combined extract shows significant analgesic, depressive, and anxiolytic effects in rats, which calls for more research into how it could be used therapeutically.
Keywords: Nyctanthes arbor-tristis, Clitoria ternatea, analgesia, neuropharmacology, herbal combination, mice model.
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