NEPHROPROTECTIVE ACTIVITY OF TAMARINDUS AND PITHECELLOBIUM DULCE FRUITS EXTRACT IN EXPERIMENTAL RATS
Md. Faheem Bari*, Dr. Ravi Prakash, Mr. Rahim khan, Mr. Ankit Mehra
ABSTRACT
This study evaluated the nephroprotective potential of Tamarindus indica and Pithecellobium dulce, individually and in combination, through phytochemical analysis, acute toxicity assessment, and in vivo renal function studies. Plant materials were collected, authenticated, and subjected to methanolic, aqueous, and petroleum ether extraction. Phytochemical screening confirmed the presence of bioactive compounds, including phenols, flavonoids, alkaloids, tannins, proteins, and glycosides. Acute oral toxicity studies demonstrated that the extracts were safe up to 2000 mg/kg, with no observable adverse effects. Polyherbal and single-plant formulations were administered to Wistar rats, resulting in improved renal parameters, including enhanced urine output and reduced serum creatinine and blood urea nitrogen levels. Histopathological examination supported these findings, revealing preservation of glomerular and tubular structures, particularly in Pithecellobium dulce-treated groups. Overall, the results validate the traditional use of these plants for renal protection, highlight the superior efficacy of Pithecellobium dulce, and provide a scientific basis for the development of safe, effective herbal formulations targeting kidney health.
Keywords: Tamarindus indica, Pithecellobium dulce, Nephroprotection, Phytochemical screening, Serum creatinine, Blood urea nitrogen.
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