European Journal of Biomedical and Pharmaceutical Sciences

UNLOCKING NATURE'S PHARMACOLOGICAL FRAMEWORK: AN IN-SILICO EXPLORATION OF CARICA PAPAYA LINN’S THERAPEUTIC POTENTIAL

Abhirami V.*, Atul Thorat

ABSTRACT

Carica papaya Linn. (CP), commonly known as papaya, is a tropical plant of considerable ethnomedicinal and nutritional importance. Traditionally utilized in Indian medicine for managing various ailments, including cancer, its fruit, leaves, and seeds have been recognized for therapeutic potential. This study investigates the pharmacological potential of C. papaya through an in-silico pharmacological and pharmacognostic approach. Phytochemicals were retrieved from curated databases, including IMPPAT, and evaluated using the SwissADME platform to assess their pharmacokinetic profiles. Key parameters analyzed included Absorption, Distribution, Metabolism, and Excretion (ADME), along with drug-likeness, lipophilicity, and solubility indices. The computational screening identified a diverse array of bioactive compounds such as flavonoids, alkaloids, terpenoids, and phenolics, exhibiting favorable pharmacological characteristics and strong oral bioavailability. Several phytoconstituents displayed compliance with major drug-likeness filters, suggesting their potential as lead molecules in drug discovery. These findings reaffirm the pharmacological significance of C. papaya and support its traditional medicinal use. Using these data of chemicals found in papaya, through in silico evaluation, this study provides a foundational framework for subsequent experimental validation through in vitro and in vivo assays to elucidate the molecular mechanisms underlying the pharmacological activity of papaya derived compounds.

Keywords: Carica papaya, ADME, IMPPAT, In silico, Pharmacological, Phytomedicine, Phytocompounds, Therapeutic agents.