Abstract
IDENTIFICATION OF DEGRADANTS OF THERMAL AND OXIDATION STRESS STUDIES OF EMPAGLIFLOZIN AND LINAGLIPTIN TABLETS BY HPLC-PDA AND LC-MS INSTRUMENTAL TECHNIQUES

Bheemi Reddy Ashok Reddy*, Mukund Reddy Bembadi, Shiva Krishna Kumari Gudisheva, Dr. Akuthota Ashok Kumar*, Dr. Rajesh Vooturi

ABSTRACT

Objective of the manuscript is to identify the degradants observed in the thermal and oxidation degradation sample of Empagliflozin and Linagliptin tablets by using LC-MS and HPLC-PDA instrumental techniques. Thermal and oxidation degradation samples were injected in HPLC-PDA and LC-MS instruments. Mass of the degradants were detected by LC-MS technique, which were assigned to the probable structures correlating with the impurities mentioned in the literature. The assigned probable structures for the degradants were confirmed by procuring and confirming by injecting in HPLC-PDA detector and LC-MS instruments.

Keywords: Empagliflozin and Linagliptin Tablets, Impurities, Degradants, HPLC-PDA, LC-MS.


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