SYNTHESIS, CHARACTERIZATION, SPECTRAL AND ANTIFUNGAL STUDIES OF Ni(II) AND Zn(II) COMPLEXES DERIVED FROM 2-AMINOPYRIMIDINE-2-THIOPHENECARBOXALDIMINE
Chandra Prabha Rajpoot*, Bharti Jain, Suman Malik, Archana Singh, Gauri Shankar Rajpoot, Anjul Dadoria
ABSTRACT
Schiff bases are an important class of compounds characterized by the presence of an imine (–C=N–) functional group, which imparts remarkable coordination ability towards metal ions. In the present work, Schiff bases were synthesized through the condensation of aldehydes with primary amines, followed by the synthesis of their corresponding Ni(II) and Zn(II) metal complexes. The synthesized compounds were characterized using standard physicochemical and spectroscopic techniques to confirm their structures. The antifungal activities of both Schiff bases and their Ni(II) and Zn(II) complexes were evaluated against selected fungal strains. The results revealed that the metal complexes exhibited enhanced antifungal activities compared to the free Schiff bases, indicating that complexation plays a crucial role in improving biological efficacy. This study underscores the potential of Ni(II) and Zn(II) Schiff base metal complexes as promising candidates for the development of novel antifungal agents.
Keywords: Schiff Base, Metal Complexes, Synthesis, Antifungal Activities.
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