SUSTAINABLE NANOTECHNOLOGY THROUGH GREEN-SYNTHESIZED CUBOSOMES: A NEW HORIZON IN DRUG DELIVERY
Gadhave Ankita*, Sameer Shafi, Swami Shivlila, Waghmare Pranita, Damane Madhuri
ABSTRACT
Cubosomes, also referred to as lyotropic cubic liquid crystalline nanoparticles (NPs), are innovative nanocarriers that have attracted considerable attention for their efficiency in targeted and controlled drug delivery. These nanosystems are typically composed of amphiphilic lipids such as glyceryl monooleate and phytantriol, which spontaneously self-assemble in aqueous environments to form a bicontinuous cubic nanostructure capable of encapsulating both hydrophilic and lipophilic therapeutic agents. Incorporation of biocompatible stabilizers and natural polymers, including Pluronic F127, chitosan, and alginate, enhances their stability, safety, and loading efficiency. In recent years, green synthesis strategies utilizing plant extracts and natural surfactants have gained prominence for producing cubosomes through sustainable, non-toxic, and environmentally friendly methods. Preparation techniques such as top-down and bottom-up approaches enable control over particle characteristics and formulation performance. Due to their biodegradability, bio adhesive nature, and prolonged drug-release potential, green-synthesized cubosomes represent a promising platform for advanced pharmaceutical applications, including transdermal, ocular, oral, and anticancer drug delivery.
Keywords: Cubosomes, Green synthesis, Pluronic F127, Nanocarriers, Sustainable formulation etc.
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