FETO-MATERNAL OUTCOMES OF RARE HAEMATOLOGICAL DISORDERS IN PREGNANCY
Dr. Prachi Singhee*, Dr. Nasrin Fatima, Dr. Rachita Garg, Dr. Pallavi Pathak, Dr. Latika Sahu, Dr. Amrit Adarsh
ABSTRACT
Background: Rare haematological disorders in pregnancy pose significant risks to both the mother and fetus due to haemostatic and hematologic challenges. Objective: To study the etiology, clinical presentation, and feto-maternal outcomes of rare haematological disorders during pregnancy. Methods: This prospective observational study was conducted over one year (October 2023–2024) at a tertiary care hospital and included 20 antenatal women diagnosed with rare haematological disorders, excluding nutritional anemia and gestational thrombocytopenia. Maternal and neonatal outcomes were assessed. Results: Among 6,400 pregnant women, the incidence of rare haematological disorders was 0.3%. The most common disorders were β-thalassemia trait (55%), immune thrombocytopenic purpura (20%), and pancytopenia (15%). Blood transfusion was required in 70% of cases, and postpartum hemorrhage occurred in 35%. Fetal complications included low birth weight (35%), meconium aspiration (40%), and intracranial hemorrhage (10%). Half of the neonates required NICU admission. Conclusion: Early diagnosis and multidisciplinary management are crucial to reduce maternal morbidity, peripartum hemorrhage, and adverse neonatal outcomes in pregnancies complicated by rare haematological disorders.
Keywords: pregnancy, rare haematological disorders, feto-maternal outcomes, thalassemia, immune thrombocytopenic purpura, von Willebrand disease, postpartum haemorrhage.
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