FORMULATION AND EVALUATION OF GREWIA ASIATICA L. TABLETS FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS
Abhishek Raj*, Dr. Amit Sharma
ABSTRACT
The primary objective of this study was to formulate tablets containing fruits extract of Grewia asiatica L. in which the dose of Grewia extract was 500 mg. The tablets were prepared by wet granulation method using microcrystalline cellulose and mannitol as diluents; croscarmellose sodium, crospovidone and sodium starch glycollate as super disintegrants; Aerosil as a glidant and magnesium stearate as a lubricant. Any excipient in the form of a binder was not used as Grewia extract had a sticky nature and believed to act as a self-binder. Purified water was used as a solvent. The prepared tablets were evaluated for various physicochemical parameters such as drug-excipient interaction by FTIR, flow properties, hardness, weight variation, thickness, friability, disintegration time and uniformity of content. These tablets were also subjected for real time and accelerated stability studies as per ICH guidelines. These tablets were found to be stable even after 6 months of stability study as all the parameters were within limit as per the specifications
Keywords: Diabetes, Grewia asiatica, Phalsa, Sharbat berry, Nutraceutical, Antidiabetic
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