European Journal of Biomedical and Pharmaceutical Sciences

IN SILICO NETWORK PHARMACOLOGY ANALYSIS AND MOLECULAR DOCKING STUDIES OF SIDDHA HERBAL PREPARATION- SANJEEVI THYLAM AGAINST URTICARIA

P. M. Thangamalar, K. Vignesh*, K Vinitha

ABSTRACT

Background and Objective: Siddha, one of the Traditional medicinal systems in India is undoubtedly known for its varied unique approach towards prevention, diagnosis as well as treatment of every disease. An ample of literary evidence on medicinal formulations are found in Siddha literatures whose scientific validation are still partial. Urticaria which is mentioned in Siddha as “Kaanakadi” is said to be a skin condition that is characterized by errythematous, edematous, itchy and transient plaques involving the mucous membrane of skin. 15 to 20 % of world population are affected by Urticarial diseases. A strong scientific approach towards treatment perspectives is needed since the disease affects both physical and social well being of the individuals. Many Siddha formulations for Kaanakadi are mentioned in literatures. One among them is the “Sanjeevi thylam” mentioned in "Chikicha rathna deepam". A proper scientific Validation of this formulation could pave way to Evidence based Medicine, which is the foundation of scientific community. Materials and Methods: Preliminary molecular docking study through computational analysis was done with the Auto Dock tool to study the efficacy of Sanjeevi Thylam against Urticaria. The binding action of major phytoconstituents of the drugs in Sanjeevi thylam against various targets were documented. Results and Discussion: Most of the phytochemicals of drugs present in Sanjeevi thylam showed significant binding capacities against the targets Histamine H1 receptor inhibitor and IL13. Hence it can be chosen for the treatment and management Urticaria. Conclusion: The Siddha herbal preparation "Sanjeevi thylam" has inherent action against Urticaria by binding with various targets was concluded by the present study.

Keywords: Siddha, Urticaria, Sanjeevi thylam, Kaanakadi.