AN EXPERIMENTAL PHYTOCHEMICAL INVESTIGATION AND ASSESSMENT OF NEPHRO PROTECTIVE ACTIVITY OF VARIEGATED CROTON PLANT EXTRACT ON EXPERIMENTAL RATS
Muskan Kumari Pandey*, Dr. Abhishek Sharma, Mr. Ritesh Malvi, Dr. Surendra Jain
ABSTRACT
The search for effective nephroprotective agents from natural sources has become crucial in combating the
increasing prevalence of kidney diseases. This study investigates the nephroprotective effects of Variegated
Croton , a plant with a long history of traditional use in treating kidney related disorders. Nephrotoxicity was
generated in Wistar rats with nephrotoxic drugs, and the potential protective benefits of Variegated Croton extract
were comprehensiv ely investigated. The extract is high bioactive chemicals including phenolics and flavonoids,
revealed strong antioxidant activity in the DPPH assay, implying that it can reduce oxidative stress, which is a
primary cause of kidney injury. The results showe d that the extract considerably improved renal function, as seen
by lower serum creatinine and blood urea nitrogen (BUN) levels and a noticeable rise in urine output. These
findings demonstrate the extract's capacity to promote renal filtration and prevent malfunction. Histopathological
investigation validated the nephroprotective effects by revealing a decrease in kidney damage, including tubular
necrosis, glomerular damage, and inflammation. These findings collectively support the concept that Variegated
Croton has strong nephroprotective qualities, which are most likely mediated by antioxidant and anti
inflammatory pathways, supporting its traditional use and indicating its potential as a therapeutic agent for kidney
protection.
Keywords: Nephroprotectiv e, Variegated Croton , Plant extract, Antioxidant, DPPH assay, Nephrotoxicity, Renal function, Serum creatinine, Blood urea nitrogen (BUN), Histopathology, Wistar rats.
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