NATURAL HERBAL AGENTS IN THE REGULATION OF BLOOD GLUCOSE: SCREENING ASSAYS AND THEIR DIVERSE PHARMACOLOGICAL ACTIONS
Shivam, Neelottama Swatantra Kumar Singh Kushwaha
ABSTRACT
Historically, symptoms that are today recognized as diabetes mellitus were treated with herbal remedies in various
cultures. Determin ing the effectiveness, mechanisms, and safety of botanicals and their active ingredients in
glycemic control has rekindled scholarly interest due to the rise in complementary and alternative medicines as
well as the advancements in phytochemistry, pharmaco logy, and screening technologies. The current evidence on
commonly studied antidiabetic herbs, the physiological and molecular pathways they control, the in vitro and in
vivo testing used to screen and profile antidiabetic effects, and the difficulties in translating botanical drug
candidates to the clinic are all summarised in this review. The primary focus is on agents with the best preclinical
and clinical signals (such as Momordica charantia, Trigonella foenum graecum, berberine containing species,
Gymnema sylvestre, Moringa oleifera, and Cinnamomum verum), assay cascade projects that combine cell based,
animal, in silico, and biochemical approaches, and practical considerations of standardisation, safety, and herb
drug interactions. The article concludes with clinical research priorities, quality and patient safety measures, and
best practice s for screening pipelines.
Keywords: Herbal remedies, glycemic control, antidiabetic, safety, efficacy, clinical research.
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