European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF FILM FORMING MICRO EMULION OF GARLIC EXTRACT CONTAINING POLYSULFANE DERIVATIVES TO POTENTIALLY INHIBIT THE SPREAD OF MELANOMA

Nitesh, K. Deekshitha*, F. M. Celvia, A. R. Shabaraya

ABSTRACT

Melanoma is a dangerous form of skin cancer caused by melanocytes, the cells that produce melanin. Although
less prevalent, it is extremely lethal due to its ability to metastasis to internal organs. Chemotherapy has long been
the primary treatment for metastatic melanoma, but it has serious adverse effects due to its non-selective action on
healthy cells. As a result, there is a rising interest in combining herbal treatments with innovative drug delivery
devices to improve treatment outcomes while reducing toxicity. Garlic (Allium sativum), which is widely used in
traditional medicine, has strong anti-cancer capabilities due to the presence of sulfur-containing chemicals such as
S-allyl cysteine, alliin, and ajoene. In multiple investigations, these bioactive’s have showed promise in
preventing melanoma cell proliferation and metastasis. As a result, the current study sought to create a stable and
effective film-forming microemulsion using garlic extract to treat melanoma. The formulation was tested for its
capacity to create films. The current study concludes that the herbal film-forming microemulsion provides a
natural, safe, and effective method against melanoma, offering a promising alternative to traditional chemotherapy
therapies.

Keywords: Melanoma, Garlic (Allium sativum), S-allyl cysteine(SAC), Alliin, Film forming microemulsion.