FORMULATION AND EVALUATION OF TRANSDERMAL PRONIOSOMAL GEL FOR GLIPIZIDE
Ankit Kumar* S. Parthiban and G. P. Senthil Kumar
ABSTRACT
The aim of the present investigation was to design a proniosomal gel system of Glipizide for the treatment of type
- 2 diabetes mellitus that is capable of delivering entrapped drug over an extended period of time. Skin has a very
tough diffusion barrier inhibiting penetration of drug moiety which is rate limiting barrier for penetration of drugs.
There are several approaches that deal with penetration enhancement across the skin. Vesicular and provesicular
systems are promising amongst them. Vesicular systems including (niosomes, ethosomes, transfersomes and
liposomes) are promising systems to cross this permeation barrier. But their major drawback is their unstability,
which can be overcome by using provesicular approaches like proniosomes, protransfersomes and proliposomes.
Provesicular approaches have been proposed to enhance the stability of vesicles. These approaches may overcome
skin barrier properties and enhance percutaneous absorption. In these systems both type of drugs, hydrophilic and
lipophillic drugs can be incorporated. Proniosomal gel of Glipizide was prepared by coacervation phase separation
technique by varying the composition of drug, span 40, soya lecithin and cholesterol. Proniosomal gel
formulations were characterized for pH, Vesicle size, Drug content, Entrapment efficiency, Surface morphology,
zeta potential, in-vitro drug release, kinetic model, stability studies.
Keywords: Glipizide, Proniosome, Entrapment Efficiency, span 40, cholesterol etc.
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
