European Journal of Biomedical and Pharmaceutical Sciences

DEVELOPMENT AND CHARACTERIZATION OF EXTENDED RELEASE SWELLABLE TABLETS OF VALSARTAN

Dr. Shaik Md. Zakir Hussain*, Dr. S. Vijay Kumar, K. R. Manasa and G. Swapna

ABSTRACT

A gastro retentive, controlled release drug delivery system of Valsartan was formulated in an effort to increase the gastric retention time of the dosage form and to control drug release. Various grades of HPMC viz., HPMCK100M, HPMCK15M, HPMCK4M were incorporated for gel forming properties. Buoyancy was achieved by adding an effervescent mixture of sodium bicarbonate and anhydrous citric acid. In vitro drug release studies were performed, and drug release kinetics was evaluated using the zero order, first order, Higuchi’s model and Korsmeyer-peppas kinetic models. The kinetic study results suggested that the drug was released by fickian diffusion in case of all the developed floating matrix tablet formulations of Valsartan The biological half-life (3-6 hours) and maximum absorption in initial part of gastro intestinal tract of Valsartan favours development of gastro retentive floating dosage form. In the present study Valsartan floating tablets were prepared by effervescence method using sodium bicarbonate and citric acid as a gas generating agent. The drug-excipient compatible studies were performed by FTIR, and the study revealed that there is no drug excipient interaction. The prepared floating tablets were evaluated for various physicochemical parameters. The in-vitro drug release pattern of Valsartan floating tablets was fitted to different kinetic models which showed highest regression for zero order kinetics with Higuchi mechanism.

Keywords: Valsartan, Floating tablets, HPMC, Eudragit, direct compression, Effervescent system, sustained release.