Abstract
FORMULATION AND EVALUATION OF CIMETIDINE SUSTAINED RELEASE TABLETS USING NATURAL POLYMERS

Kate Siddheshwar Arjun*, Sunil K. Shah, Deepak Basedia, B. K. Dubey, Mukesh K. Patel

ABSTRACT

The present study aimed to formulate and evaluate gastroretentive sustained-release tablets of Cimetidine using natural polymers. Preformulation studies confirmed the purity and suitable physicochemical properties of the drug. Sustained-release tablets were prepared by the direct compression method using polymers such as Xanthan Gum, Gellan Gum, Chitosan, and Carbopol 940. The formulations were evaluated for pre-compression and post-compression parameters such as hardness, friability, weight variation, drug content, and floating behavior. All formulations met pharmacopeial limits and showed floating duration of more than 12 hours. In-vitro dissolution studies indicated controlled drug release up to 12 hours, with formulations F7 and F8 showing the best sustained-release profile. The results suggest that natural polymer-based floating tablets of Cimetidine HCl can provide prolonged gastric retention and controlled drug release.

Keywords: Cimetidine HCl; Sustained release tablets; Gastroretentive system; Floating tablets; Natural polymers.


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