PHYSICOCHEMICAL, PHYTOCHEMICAL AND SAFETY EVALUATION OF SIDDHA HERBO-MINERAL FORMULATION MILAGU MATHIRAI PREPARED ACCORDING TO CLASSICAL SIDDHA LITERATURE
Dr. Keerthana J.*, Dr. Muhilan A., Dr. Essakkypandian G.
ABSTRACT
The Siddha system of medicine includes numerous classical formulations used for the management of respiratory diseases. Scientific standardization of these medicines is essential in order to ensure their quality, purity, and safety. The present study was undertaken to evaluate the physicochemical characteristics, phytochemical constituents, and safety parameters of the traditional Siddha herbo‑mineral formulation Milagu Mathirai prepared according to the classical text Anubava Vaithiya Kalanjiyam (M.S.S. Assan, 1992). Analytical investigations were carried out in accordance with PLIM guidelines. The evaluation included organoleptic analysis, physicochemical testing, weight variation, disintegration study, preliminary phytochemical screening, microbial load determination, heavy metal estimation, pesticide residue analysis, and aflatoxin detection. The formulation showed acceptable physicochemical values including loss on drying (6.03 ± 1.30%), total ash (0.83 ± 0.16%), absence of acid‑insoluble ash, and a pH of 6.7. Phytochemical analysis revealed the presence of alkaloids, flavonoids, steroids, triterpenoids, coumarins, phenols, tannins, saponins, sugars, and betacyanins. Heavy metals, microbial contamination, pesticide residues, and aflatoxins were not detected within the tested limits. The results indicate that Milagu Mathirai satisfies standard safety and quality requirements and supports its traditional use in respiratory disorders. Further pharmacological and clinical studies are recommended.
Keywords: Milagu Mathirai, Siddha Medicine, physicochemical analysis, phytochemical screening, safety evaluation.
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