Abstract
FORMULATION, DEVELOPMENT AND EVALUATION OF MEMANTINE FAST DISSOLVING TABLETS USING NATURAL POLYMERS

Shelar Prajyot Narayan*, Vivek Singh Thakur, Sunil K. Shah, Deepak Basedia, B. K. Dubey

ABSTRACT

The present study aimed to formulate and evaluate fast dissolving tablets of Memantine using natural polymers. Memantine is used in the treatment of Alzheimer’s disease, and fast dissolving tablets improve patient compliance by disintegrating quickly in the oral cavity without water. Preformulation studies confirmed the purity and suitability of the drug for formulation. Tablets were prepared by the direct compression method using natural polymers such as guar gum and xanthan gum along with superdisintegrants. The prepared formulations were evaluated for pre-compression and post-compression parameters including flow properties, hardness, friability, weight variation, drug content, disintegration time, and in-vitro drug release. Among all formulations, F3 showed the best performance with rapid disintegration (45 seconds) and 98.85% drug release within 15 minutes. The study concluded that Memantine fast dissolving tablets using natural polymers provide rapid drug release and improved patient compliance.

 

Keywords: Memantine, Fast Dissolving Tablets, Natural Polymers, Direct Compression, Superdisintegrants, In-vitro Drug Release, Alzheimer’s Disease.


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