European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF LIPOSOME LOADED ANTI-TUBERCULAR TRANSDERMAL PATCH OF CLERODENDRUM INFORTUNATUM (L.)

Sanfia Mol M.*, Sneha S., Eshanika S.,3Kavya K., Pratheesh K., Dr. Sapna Shrikumar

ABSTRACT

Cutaneous tuberculosis (CTB) is a difficult skin infection that requires targeted and long-lasting drug delivery to improve treatment results. Clerodendrum infortunatum (Lamiaceae) has shown strong antitubercular and anti-inflammatory properties due to its flavonoids, alkaloids, and terpenoids. In this study, we extracted the plant leaves using Soxhlet extraction with petroleum ether at 60–80 °C to create a defatted, lipophilic extract rich in antitubercular compounds. We added the petroleum ether extract to liposomes made by the solvent evaporation method using soya lecithin and cholesterol to enhance skin absorption and reduce overall toxicity. We characterized the liposomal dispersion by measuring particle size, zeta potential, and using scanning electron microscopy (SEM). We then loaded the optimized liposomal formulation into a polymeric transdermal patch made from a hydrophilic polymer matrix such as HPMC, ensuring steady delivery at the infection site. We evaluated the physical and mechanical properties of the patch, including thickness, appearance, spreadability, pH test, and absorbency

Keywords: Clerodendrum infortunatum, petroleum ether extract, Soxhlet extraction, liposomes, transdermal patch, cutaneous tuberculosis.