FORMULATION AND EVALUATION OF LEVOFLOXACIN OPHTALMIC INSITU GEL
K. Harika*, K. C. Manasa, S. Vijayalakshmi, P. Arun Kumar, R. Pallavi
ABSTRACT
The present study focuses on the formulation and evaluation of Levofloxacin ophthalmic in situ gel for the
effective treatment of ocular infections. Conventional eye drops show poor bioavailability due to rapid tear
drainage and short pre corneal residence time. To overcome these limitations, an in-situ gelling system was
developed to enhance ocular retention and provide sustained drug release. The Formulation was prepared using
thermo sensitive and or pH-sensitive polymers polymers that exhibit sol-to- gel phase transitions due to change in
specific physicochemical parameter such as (pH, temperature), in their environment, the cul-de-sac in this case
such as carbopol 934. The prepared formulations were evaluated for clarity, pH, viscosity, drug content, gelation
capacity, in vitro drug release, sterility, Rheological, Isotonicity test, Microbial Assay and stability test was
performed. All formulations were found to be clear, with pH within the acceptable ocular range and uniform drug
content. Viscosity studies confirmed sol-to-gel transition under physiological conditions. In vitro drug release
studies demonstrated sustained release of Levo-0floxacin over an extended period compared to conventional
ophthalmic solutions. The optimized formulation showed appropriate gelation behavior, prolonged drug release,
and satisfactory stability. The study concludes that levofloxacin ophthalmic in situ gel is a promising alternative to conventional eye drops, offering improved bioavailability, reduced dosing frequency, and enhanced patient
compliance in the management of bacterial eye infections.
Keywords: Opthalmic, insitu gel, L.ofloxacin.
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