European Journal of Biomedical and Pharmaceutical Sciences

SUSTAINED CLINICAL IMPROVEMENT IN PSORIASIS ASSESSED BY PSORIASIS AREA SEVERITY INDEX (PASI) SCORE FOLLOWING STEROID-FREE POLYHERBAL TREATMENT: A CASE SERIES

*Dr. Darshan Desai

ABSTRACT

Psoriasis is a chronic immune-mediated skin disorder with recurrent episodes, significant comorbidities, and
impaired quality of life. Limitations of conventional therapies and fear of recurrence highlight the need for safe
and sustainable alternatives. Present case series aims to evaluate the clinical outcomes of an Ayurveda-based
structured therapeutic protocol in patients with chronic psoriasis. This case series included nine patients diagnosed
with psoriasis based on clinical examination and Psoriasis Area Severity Index (PASI) scoring. A structured,
phased Ayurvedic treatment protocol using a core group of herbal formulations was administered with
individualized modifications. Patients were followed for 7–24 months. Clinical outcomes were assessed using
changes in PASI scores and symptom improvement. All patients demonstrated substantial reduction in PASI
scores, with improvement ranging from approximately 70% to 100%. Most patients showed marked or good
clinical improvement, with reduction in itching, scaling, and associated symptoms. Sustained benefits were
observed in the majority of cases, with minimal recurrence and no reported adverse effects. The findings suggest
that present structured Ayurvedic therapeutic protocol may offer effective and sustained clinical improvement in
psoriasis. Further randomized controlled trials with standardized outcome measures are warranted to validate these
results.

Keywords: Ayurveda, PASI score, Steroid-free treatment, Chronic Psoriasis, Neem, Herbal Treatment.