IN VITRO STUDIES ON THE EVALUATION OF SELECTED MEDICINAL PLANTS FOR LUNG CARCINOMA
Khalidah Khalaf Jabbar, Jaffar S. K., Ganesh Dama, Balasubramanian Sathyamurthy*
ABSTRACT
The present study describes the anticancer, hemolysis and antimicrobial and DPPH assay, NOS assay, MTT assay
of Neem, lemon, cinnamon extracts were prepared from these plants and their hemolytic, anticancer and
antimicrobial activities were evaluated. First the hemolytic activities of the plants were tested on human
erythrocytes so as to check the toxicity of the plants selected. The results showed that the percentage of hemolysis
of all the samples were less so they are considered as non toxic. The antiproliferative activity of the plants was
studied on non-small lung cancer cell line A549 and cell viability was assessed by MTT assay and non linear
regression graph was made by using graph pad prism. The result showed a dose dependent behavior of the extract
cinnamon and it exhibited an IC50 value of 21.9 μg / ml towards the lung cancer cell line A549. The antibacterial
activity and antifungal activity was measured by disc diffusion method on S.Pyagenes and Alricanes. There is no
zone of inhibition was observed against the bacterial pathogen S.Mutans when it compared with the stranded
fluconazole, ciproflaxacin antibiotics. These obtained results have showed that cinnamona can be considered as a
promising chemotherapeutic agent that can be used for lung cancer treatment.
Keywords: Cinnamon, Lemon, Neem, DPPH, NOS, MTT Assays.
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