PHARMACOLOGICAL EVALUATION OF CRATEVA RELIGIOSA, LEAVES AQUEOUS EXTRACT FOR CENTRAL NERVOUS SYSTEM DEPRESSANT ACTIVITY IN MICE
Kanakam Vijayabhaskar*, Renukuntla Pranay, Karra Ujwala, Anagandhula Sushma Reddy, Uppari Naresh, Kalakota Chaitanya prasad
ABSTRACT
Crateva religiosa, is called the sacred garlic pear and, belongs to the family capparaceae, is a medicinal plant
widely used in Ayurveda to treat painful conditions, The drug is well known for its various pharmacological
properties like diuretic, antiinflammatory, laxative, antioxidant, antioxaluric, hepatoprotectant, lithonotriptic,
antirehumatic, antiperiodic, antimycotic, contraceptive, antipyretic, antilithitic, antihelminthic, rubifacient and
vesicant properties. The present study was carried out to evaluate the central nervous system depressant activity of
different extracts of Crataeva religiosa leaves, extracted successively with petroleum ether, chloroform, methanol
and water respectively depending upon their polarity. CNS depressant activity was evaluated using pentobarbitone
induced sleeping time and by determining locomotor activity using actophotometer. Aqueous extract of Crataeva
religiosa leaves (400 mg/kg) produced highest activity as it significantly (P<0.01) reduced the onset and prolonged
of sleep duration induced by pentobarbitone, extract also decreased locomotor activity by 67.33%. Chloroform and
methanol extract also produced dose dependent CNS depressant activity. Though petroleum ether extract does not
produce significant CNS depressant activity in both models. The results indicate that different extracts of Crataeva
religiosa leaves possesses CNS depressant activity.
Keywords: Crataeva religiosa, Pentobarbitone, Locomotor activity, Aqueous extract.
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