EVALUATION OF LIPID PROFILE IN PATIENTS ON ATYPICAL ANTI PSYCHOTIC MEDIACTIONS
*E. Sam Jeeva Kumar, R. Anushasri, T. Mahendra, N. Prasad and Dr. Deepika
ABSTRACT
The use of atypical antipsychotics was reported to cause the variation in the lipid levels, i.e. triglyceride levels
(TG), cholesterol levels (TC), LDL and HDL levels in the patient which is a precursor to many cardiac disorders.
The aim of the study is to assess the variations of lipid levels in patients associated with atypical antipsychotics.
This study is designed as a Prospective Observational Study (Follow-Up study) which was carried out in
Psychiatric department of Rajiv Gandhi Institute of Medical Science, Kadapa and MNR Hospital, Hyderabad
simultaneously for a period of 9 months. The patient’s base-line values of lipid profiles (TG, TC, HDL and LDL)
were recorded and regular follow-ups were done for every 4 weeks until 4 months and finally the variations
associated with atypical antipsychotics were assessed. We have recruited 46 patients based on the eligibility
criteria. The baseline values were normal and at end of the study the lipid profiles of patients were altered, i.e.
increased values total cholesterol, triglyceride levels and there were no significant changes in the HDL and LDL
levels with the use of atypical antipsychotics. The drugs tends to cause variations in the lipid levels of patients fall
in the order, OLANZAPINE (10mg) > CLOZAPINE (10mg) + RISPERIDONE (3mg) > RISPERIDONE (3mg) >
OLANZAPINE (5mg) > OLANZAPINE (10mg) + CLOZAPINE (50mg) > RISPERIDONE (2mg). Concluding
this research that the AAPs are producing an increased incidence of hyperlipidemia in the blood which leads to
cardiac complications, so the management of psychiatric disorders should be multidisciplinary including
psychiatrist, general physician, cardiologist and paramedical staff.
Keywords: hyperlipidemia, LDL and HDL.
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