COMPARATIVE STUDY OF SAFETY AND BENEFITS OF ORAL HORMONAL AND NON-HORMONAL CONTRACEPTIVES
Pooja Agrawal*, Virendra Kushwaha and Brij Kishore Mangal
ABSTRACT
Aims: To compare the safety and benefits of different oral hormonal and non-hormonal contraceptives
preparations. Material and Methods: A prospective observational study was carried out for duration of twelve
months at LLRM medical college and associated hospital, Meerut,UP. The cases were selected from the patients
attending post partum programme centre and outdoor department of obstetrics and gynaecology, who were taking
oral hormonal or non-hormonal contraceptives preparations. Women were asked not to use any other method of
contraception during the study. Every woman was asked to report immediately if she develops any problem after
taking pills and asked for regular follow up at every month. Results: The present study was conducted on 109
cases, among them 84 cases used hormonal oral contraceptives pills (OCPs) and 25 used non-hormonal OCPs. Out
of 84 women, 53 cases used hormonal OCPs for contraception and 31 used for other gynaecological problems.
Among hormonal OCPs users for contraception, the most common ADR reported was weight gain (32.07%)
followed by nausea/vomiting (26.41%), menstrual irregularities (16.98%), While among non-hormonal OCPs
users the most common ADR reported was menstrual irregularity (68%). OCPs caused significant improvement in
patients of dysfunctional uterine bleeding (DUB) and dysmenorrhoea. No failure rate was observed. Conclusion:
Oral contraceptives are effective in management of some important gynaecological problems and prevention of
pregnancy and are quite safe regarding adverse effect but menstrual irregularities are the major limiting factor for
its use as contraceptive.
Keywords: Adverse drug reactions, Hormonal, Non- Hormonal, Oral contraceptives pills, Menstrual irregularities.
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