European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND OPTIMIZATION OF ORALLY DISINTEGRATING TABLET OF LABETOLOL

Pawan Kumar Singh*, V. P. Gupta, Bhupendra Tiwari

ABSTRACT

Among the dissimilar routes of administration, oral way of administration continue to be the most chosen route due to different advantages including ease of intake, avoidance of pain, adaptability and most importantly patient fulfillment. The different dosage forms include tablets, capsules and oral liquid preparations. For the past two decades, there has been an enhanced demand for more patient compliance dosage forms. Thus, these conventional dosage forms result in high prevalence of noncompliance and unsuccessful therapy with respect to swallowing specially in the case of geriatric, pediatric, or any mentally retarded persons. Orodispersible tablets or orally disintegrating tablet can be easily administered in the population especially for geriatric, pediatric, or any mentally retarded persons made it a much admired dosage form. Due to the existence of super disintegrants, it gets dissolved quickly, resulting in speedy absorption of drug which provides rapid onset of action. The primary scope of the research is to prepare and evaluate oro dispersible labetolol tablets to overcome the limitations of ordinary tablet formulation.

Keywords: Orodispersible, disintegrating tablet geriatric, pediatric, super disintegrants.