European Journal of Biomedical and Pharmaceutical Sciences

ORAL DISPERSIBLE FILMS: AN OVERVIEW OF FORMULATION, EVALUATION AND RECENT TRENDS

Anushree Madhukar Atre*, Amol Sampat Deshmukh, Shivshankar Shalikram Ambhore

ABSTRACT

Oral dispersible Films (ODFs) are drug delivery systems that are produced using a variety of techniques for both small-scale pharmacies and personalized medications on a large scale. ODFs and the processes used to fabricate them have some drawbacks. In order to address these problems and discover novel formulations for a variety of APIs that might make their job profitable for them as well as useful for patients, numerous pharmaceutical corporations and academic research institutions worldwide collaborate. This review paper's objective is to offer details on ODF formulation, manufacture, and characterization. ODFs are innovative dosage forms that break down and dissolve in the mouth. Intra-oral absorption lowers the unit dose required to provide the intended therapeutic effect by facilitating rapid action and preventing first-pass effects. These thin, flexible films provide a potential therapeutic approach in the realm of pharmacological intervention since they are made to rapidly dissolve when they come into touch with saliva. The film is made using a variety of materials, including plasticizers, medications, and organoleptic compounds. The film's regular structure and efficacy depend on these components. To increase the flexibility and durability of film materials, for instance, plasticizers are substances that are added. They work by lowering the tension between polymer chains, which makes the film more elastic and resilient to breaking or cracking. Conversely, medications are integrated into the film's structure to achieve certain therapeutic objectives. In addition to examining the crucial elements involved in the packaging process, this study aims to give a thorough overview of the basic ideas and procedures that control the creation and assessment of film.

Keywords: Buccal cavity, polymeric film, oral dispersible film, new drug delivery, and solvent extraction technique.