IMPROVEMENT OF SOLUBILITY OF TERBINAFINE HYDROCHLORIDE BY USING SOLID DISPERSION
*Mr. Akash Shete, Dr. Sudke S. G.
ABSTRACT
Terbinafine hydrochloride is a widely used antifungal drug; however, its therapeutic effectiveness is limited due to its poor aqueous solubility and low oral bioavailability. The present study aims to enhance the solubility and dissolution rate of terbinafine hydrochloride using solid dispersion techniques. Solid dispersions were prepared using different hydrophilic carriers such as hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP), urea, and citric acid in varying drug-to-polymer ratios by the solvent evaporation method. Preformulation studies, including UV spectroscopy, confirmed the λmax of the drug at 283 nm, and calibration curves demonstrated good linearity (R² = 0.9977). Fourier Transform Infrared (FTIR) spectroscopy studies revealed no significant interaction between the drug and carriers, indicating compatibility. In vitro dissolution studies showed a significant improvement in the dissolution rate of terbinafine hydrochloride in solid dispersion formulations compared to the pure drug.Among all carriers, HPMC exhibited the highest enhancement in solubility and dissolution, followed by PVP, citric acid, and urea. The increase in dissolution rate is attributed to improved wettability, reduced particle size, and conversion of the drug into an amorphous form. In conclusion, solid dispersion is an effective technique for enhancing the solubility and dissolution rate of poorly water-soluble drugs like terbinafine hydrochloride, thereby potentially improving its bioavailability and therapeutic efficacy.
Keywords: Terbinafine hydrochloride, Solid dispersion, Solubility enhancement, HPMC, Dissolution rate, FTIR.
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