IN-VITRO EVALUATION OF ANTI-PSORIATIC ACTIVITY AND PHYTOCHEMICAL SCREENING OF ARGEMONE MEXICANA LEAF EXTRACT
*Mr. Sachin Kumbhar, Mr. Swapnil Kamble, Ms. Sakshi Kavitake, Mr. Onkar Kharade, Ms. Pooja Kharat, Ms. Snehal Kharat
ABSTRACT
Psoriasis is a chronic inflammatory skin disorder associated with oxidative stress and immune dysregulation. Medicinal plants rich in bioactive phytoconstituents are increasingly being explored as safer alternative therapeutic agents. The present study was designed to evaluate the phytochemical profile and in-vitro anti-psoriatic potential of Argemone mexicana leaf extract. Preliminary phytochemical screening revealed the presence of major secondary metabolites such as alkaloids, flavonoids, tannins, glycosides, and terpenoids. The antioxidant activity of the extract was assessed using DPPH radical scavenging assay, nitric oxide scavenging assay, and Ferric Reducing Antioxidant Power (FRAP) assay, while anti-inflammatory potential was evaluated by protein denaturation method. The results demonstrated significant antioxidant and anti-inflammatory activities in a concentration-dependent manner, indicating the presence of potent bioactive compounds. The findings suggest that Argemone mexicana leaf extract possesses promising in-vitro anti-psoriatic potential and may serve as a potential source for developing natural therapeutic agents against the oxidative stress and inflammatory skin disorders.
Keywords: Argemone mexicana, psoriasis, DPPH assay, nitric oxide scavenging, FRAP assay, protein denaturation, anti-inflammatory activity.
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