European Journal of Biomedical and Pharmaceutical Sciences

Emilia Sonchifolia, Phytochemical Screening, Wound Healing, Anti-inflammatory, Flavonoids, Pyrrolizidine Alkaloids.

Shosi Mari Larido*, Aisa Daring, Erich Anquillano, Fatima Zernahar Nanong, Erika Mae Timsan, John Jeric Teves, Gerson Balatero, Roselina Ladjaalih, Nur-Ainie Jambiran, Jona Mae Almadin, Kyle Christian Vreeland, Arkiell Dereza

ABSTRACT

Senna alata (L.) Roxb., commonly known as akapulko or ringworm bush, is a medicinal plant widely recognized in tropical and subtropical regions for its diverse pharmacological activities. This review summarizes existing literature on the phytochemistry and dermatologic applications of S. alata, with a particular focus on its potential effectiveness in treating acne. The plant is rich in bioactive compounds such as anthraquinones, flavonoids, tannins, and phenolic compounds, which are distributed across its various parts, including leaves, flowers, roots, and seeds. These constituents contribute to its documented antifungal, antibacterial, anti-inflammatory, and antioxidant properties. Notably, the anthraquinones rhein and aloe-emodin are primarily responsible for its significant antifungal effects against pathogens like Candida species and dermatophytes. Its antibacterial activity targets both Gram-positive and Gram-negative bacteria, including acne-causing Propionibacterium acnes. Furthermore, the plant's anti-inflammatory effects, attributed to compounds like quercetin and kaempferol, involve the inhibition of COX enzymes and pro-inflammatory cytokines, making it beneficial for inflammatory skin conditions. The antioxidant activity, driven by phenolic compounds, helps mitigate oxidative stress crucial in skin health. This comprehensive review highlights S. alata's promising role as a natural alternative in skincare formulations, particularly for managing acne and other dermatological conditions, by identifying its key bioactive compounds and mechanisms of action.

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