Abstract
FORMULATION AND DEVELOPMENT OF METRONIDAZOLE MUCOADHESIVE MICROSPHERES BY IONOTROPIC GELATION COMPLEXATION TECHNIQUE

C. Muralikrishna Goud*, E. Sumathamma, G. Jyothi, Dr. H. Ramana, A. Vijaya Rao and G. Venkateshwarlu

ABSTRACT

The aim of present work is to prolong the gastric residence time of metronidazole by formulating into mucoadhesive control release microspheres. Metronidazole is a Antibacterial (systemic); antiprotozoal and antiamoebic drug. The mucoadhesive microspheres were prepared by ionotropic gelation method of polyelectrolyte complexation technique using sodium alginate as control release polymer and carbopol934 as mucoadhesive polymer along with drug in different proportions and calcium chloride as agent of multivalent cations. The prepared microspheres were characterized by micrometric properties, percentage entrapment efficiency, mean particle size, invitro wash-off test, invitro release studies. The data obtained in this study suggests that a micro particulate mucoadhesive dosage form of metronidazole can be successfully formulated to give prolonged residence time of drug and hence improved bioavailability.

Keywords: gastric residence time, metronidazole, sodium alginate, carbopol 934, inotropic gelation method.


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