FORMULATION DEVELOPMENT AND EVALUATION OF CLOTRIMAZOLE LOADED TOPICAL PAINT USING NITROCELLULOSE POLYMER FOR EFFECTIVE ANTIFUNGAL THERAPY
Miss Monika N. Meshram*, Mr. Pruthviraj Meshram, Dr. Sachin B. Dhudhe
ABSTRACT
The present study was aimed at formulation development and evaluation of topical paint containing Clotrimazole for effective antifungal therapy. Fungal infections affecting skin and mucosal tissues require prolonged local treatment, and topical drug delivery systems offer advantages including localized action, reduced systemic side effects, and improved patient compliance. Clotrimazole, a broad-spectrum antifungal drug, was selected as the active pharmaceutical ingredient and Nitrocellulose polymer was selected as film-forming polymer for preparation of topical paint formulation. Preformulation studies including organoleptic properties, solubility analysis, melting point determination and drug-polymer compatibility study using Fourier Transform Infrared Spectroscopy (FTIR) were performed. Compatibility study confirmed absence of chemical interaction between drug and polymer. Eight formulations (F1–F8) were prepared by solvent evaporation method using varying polymer concentration and plasticizer concentration. Prepared formulations were evaluated for drying time, viscosity, non-volatile content, film integrity, drug content uniformity and antifungal activity using zone of inhibition method. Results indicated that optimized formulation showed satisfactory film formation, acceptable viscosity, good drug content and effective antifungal activity against fungal strain. The study concluded that Clotrimazole topical paint formulation can serve as a promising topical antifungal delivery system with improved therapeutic efficacy and patient convenience.
Keywords: Clotrimazole, Topical Paint, Nitrocellulose, Antifungal Therapy, FTIR Compatibility Study, Film Forming Polymer.
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