COMPREHENSIVE REVIEW OF ANALYTICAL METHODS FOR THE DETERMINATION OF PRAZOSIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION
Dr. G. Abirami*, E. Vishnupriya
ABSTRACT
Prazosin Hydrochloride (Prazosin HCl) is a selective α1-adrenergic receptor antagonist widely used in the management of hypertension, benign prostatic hyperplasia, and post-traumatic stress disorder-related nightmares. Accurate and reliable analytical methods are essential for the quality control, formulation development, stability assessment, and pharmacokinetic studies of Prazosin HCl. This review provides a comprehensive overview of the analytical techniques reported for the determination of Prazosin HCl in bulk drug substances, pharmaceutical formulations, and biological matrices. Various chromatographic methods, including High-Performance Liquid Chromatography (HPLC), Ultra-Performance Liquid Chromatography (UPLC), High-Performance Thin-Layer Chromatography (HPTLC), and Thin-Layer Chromatography (TLC), are critically discussed. In addition, spectroscopic methods such as UV–Visible spectrophotometry and liquid chromatography–mass spectrometry (LC–MS/MS) are reviewed. Method development parameters, validation characteristics, sensitivity, specificity, accuracy, precision, robustness, and regulatory considerations based on International Council for Harmonisation (ICH) guidelines are highlighted. Comparative evaluation of the reported methods reveals their applicability in routine quality control and research settings. This review aims to serve as a valuable reference for researchers, analysts, and pharmaceutical scientists involved in the development and validation of analytical methods for Prazosin HCl.
Keywords: Prazosin Hydrochloride, HPLC, UV Spectrophotometry, Analytical Method Development, Method Validation, Pharmaceutical Analysis, Quality Control.
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