EVALUATION OF NYCTANTHES ARBOR-TRISTIS LINN. (NAT) FLOWERS EXTRACT AGAINST EXPERIMENTALLY INDUCED PEPTIC ULCER DISEASE IN SWISS ALBINO MICE
*Sazzad Ansari, Dr. Ashutosh Mishra, Dr. Rekha Gour
ABSTRACT
The present study was undertaken to evaluate the gastroprotective and anti-peptic ulcer activity of the methanolic flower extract of Nyctanthes arbor-tristis Linn. in an ethanol-induced ulcer model in Swiss albino mice. Flowers of N. arbor-tristis were collected, authenticated by a taxonomist, shade-dried, powdered, and extracted with 90% methanol. Preliminary phytochemical screening of the extract revealed the presence of alkaloids, glycosides, flavonoids, terpenoids, tannins, saponins, and steroids, while anthraquinones were absent. Twenty-four mice were divided into four groups and gastric ulcers were induced using absolute ethanol. The animals were treated orally with N. arbor-tristis flower extract at doses of 150 and 200 mg/kg, while ranitidine was used as the reference drug. Ulcer index, percentage ulcer healing, and total gastric acidity were evaluated after 6, 10, and 14 days of treatment. The ulcerated group showed an ulcer index of 2.85 ± 0.02, whereas treatment with the extract significantly reduced the ulcer index in a time- and dose-dependent manner (P<0.05). At 14 days, the high-dose extract produced 97.26% ulcer healing, compared with 95.33% for the low-dose extract and 98.59% for ranitidine. The extract also significantly reduced elevated gastric acidity. The findings suggest that the methanolic flower extract of N. arbor-tristis possesses significant gastroprotective and anti-ulcer activity and may have potential as a source of therapeutic bioactive compounds.
Keywords: Nyctanthes arbor-tristis; Methanolic flower extract; Anti-ulcer activity; Gastroprotection; Ethanol-induced gastric ulcer.
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
