Abstract
GENETIC POLYMORPHISM OF GSTT1 AND SUSCEPTIBILITY TO LYMPHOID LEUKEMIAS

Sara Kamil Morsi Mahmoud and Ibrahim Khider Ibrahim*

ABSTRACT

Background: Glutathione S-transferase (GST) enzymes that play a key role in detoxification of activated carcinogens are shown to be one of the potential modifiers of individualized risk for several cancer types. Objective: This purpose of this study was to investigate the frequency of the GSTT1 null genotype in lymphoid leukemia (ALL and CLL) in sudan. Materials and Methods: The study was conducted among 30 patients with chronic lymphocytic leukemia among both gender at different ages and 30 patient with acute lymphoctic leukemia and 60 apparently healthy control subjects. complete blood count were performed by an automated cell analyzer. The GSTT1 nul genotype was determined using polymerase chain reaction (PCR) method. Results: The GSTT1 null polymorphism in patients with acute lymphoid leukemia was detected in 20 of patient (67%) 10 of them were male and 10 were females with insignificant, The GSTT1 null polymorphism was detected in 22 of control (23%), The GSTT1 null polymorphism in patients with chronic lymphocytic leukemia was detected in 16 of patients (53%). 13 of them male and 3 of them female, but the difference was statistically significant (OR=3.5 for both ALL and CLL, 95% CI= 1.8-4.2, P= 0.015) Conclusion: Our finding suggests that heritable GSTT1 status may influence the risk of developing CLL and ALL.

Keywords: lymphoid leukemia (ALL and CLL), Polymorphism, GSTT1.


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