EFFECT OF THE HYDROPHOBIC NATURE OF TRIACETYL ?-CYCLODEXTRIN ON THE DISSOLUTION PROPERTIES OF FENOPROFEN CALCIUM DIHYDRATE PREPARED BY KNEADING AND CO-EVAPORATING METHODS
H. O. Ammar, M. A. Nahdy, *T. S. Makram and S. Mosallam
ABSTRACT
Fenoprofen calcium dihydrate is a non- steroidal, anti- inflammatory, anti-arthritic drug. It is slightly soluble in
water and indicated for the treatment of mild to moderate pain, the recommended dosage is 200 mg given orally
every 4 to 6 hours. Therefore, the aim of this study was to attain a prolonged therapeutic effect and a reduced
incidence of side effects, sustained or controlled release formulations of fenoprofen calcium dihydrate have been
developed to maintain a suitable plasma level for a long period of time with minimal frequency of daily
administration. Method: Fenoprofen calcium dihydrate: triacetyle b-cyclodextrin (TABCD) was prepared as
physical mixture and solid binary systems were performed by kneaded and co-evaporated methods in different
ratios 1:1, 1:2, 1:3, 1:4. Results: The most appropriate technique was co-evaporating using the drug: TABCD in a
ratio of 1:3. Conclusion: The lowest DE was found for the co-evaporated complex which contains (Drug:
TABCD) in a ratio of 1:3.
Keywords: Fenoprofen calcium dihydrate, TABCD, dissolution.
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