THE RELATIONSHIP OF E2/T RATIO AS AN INDICATOR OF THE AROMATASE ACTIVITY WITH LEVELS OF ESTRADIOL, TESTOSTERONE AND BMI IN SUDANESE WOMEN WITH POLYCYSTIC OVARY SYNDROME.
Mustafa Abdelgadir Khandgawi*, Adel Nasr Morsi and Liza Hamdi Mohamed
ABSTRACT
Background: Determination of E2/T ratio provides necessary data regarded to aromatase activity which significantly plays a vital role and directly associated with the generation and metabolism of sex hormone for girls of reproductive age. Our aim was to explain the relationship between aromatase activity with levels of Estradiol (E2), Testosterone (T) levels and Body mass index (BMI) in Sudanese women with PCOS or without PCOS. Methodology: A total of 40 PCOS cases diagnosed according to Rotterdam criteria 2003 and 40 ovulatory normal – non PCOs, healthy, age-matched women as control. Serum Estradiol (E2) and Testosterone (T) on the third day of the menstrual cycle were measured using manual ELISA technique. Both E2/T ratio and Body Mass Index (BMI) were calculated. The Data management and analysis were done by SPSS version 22. Results: E2/T ratio, E2 were highly significantly lower (P < 0.01) while T levels was highly significantly higher (P < 0.01) in PCOS patients. However, no significant difference was observed in BMI of either PCOS or control. Conclusion: Our study suggests that higher testosterone levels in the ovary shut down the activity of the aromatase enzyme and improving aromatase activity may become an optimized approach for remedy options for PCOS women.
Keywords: PCOS, Armatase enzyme, Estradiol, Testosterone.
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