Abstract
SERUM TRANSAMINASE ACTIVITIES, ALBUMIN AND BILIRUBIN LEVELS IN SALT LOADED EXPERIMENTAL RATS TREATED WITH ETHANOL EXTRACT OF GONGRONEMA LATIFOLIUM.

*Ohadoma S.C. and Nnatuanya I.N.

ABSTRACT

Objective: To evaluate the effect of ethanol leaf extract of Gongronema latifolium on activities of serum transaminase, albumin, and bilirubin levels, which are indicators of liver function, in salt loaded rabbits. Material and Methods: Four groups comprising five rats each were used. Group I served as control (non-loaded with salt and non-treated with extract); Group IV received continuous salt loading; while Groups II and III were administered 100 and 300 mg/kg of extracts respectively, once daily for 14 days. The alanine transaminase (ALT), aspartate transaminase (AST), albumin (ALB) and bilirubin (BIL) levels were evaluated using Assay Kits (Randox Laboratories Ltd, United Kingdom BT 294 QY). Students t-test, ANOVA and Turkey-Kramer test were used to assess significance of difference due to administration of extract and the control. Results: Continuous salt loading showed significantly (p < 0.05) elevated serum ALT, AST, ALB and total BIL when compared with the control. Treatment with G. latifolium ethanol leaf extract, in the salt loaded rats, exhibited dose-dependent nonsignificantly (p > 0.05) compared with the control group. Conclusion: The leaf extract of G. latifolium was seen to be safe considering its effects on serum ALT, AST, albumin and bilirubin of the experimental rats; and may be useful in the management of possible deleterious effects of salt load to the liver.

Keywords: Serum transaminase, albumin, bilirubin, salt loaded, Gongronema latifolium.


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